翻訳と辞書 Words near each other ・ Diphlorethol ・ Diphone ・ Diphoorn ・ Diphosgene ・ Diphosphane ・ Diphosphate-purine nucleoside kinase ・ Diphosphate—glycerol phosphotransferase ・ Diphosphate—serine phosphotransferase ・ Diphosphene ・ Diphosphenes ・ Diphosphines ・ Diphosphoglycerate ・ Diphosphoglyceric acid ・ Diphosphoinositol-pentakisphosphate kinase ・ Diphosphoinositol-polyphosphate diphosphatase ・ Diphosphomevalonate decarboxylase ・ Diphosphorus ・ Diphosphorus tetraiodide ・ Diphosphorus tetroxide ・ Diphosphotransferase ・ Diphridas ・ Diphros ・ Diphteramoma ・ Diphthamide ・ Diphthera (moth) ・ Diphthera festiva ・ Diphtheria ・ Diphtheria toxin ・ Diphtheria vaccine ・ Diphtheritic stomatitis Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Diphosphomevalonate decarboxylase ： ウィキペディア英語版 Diphosphomevalonate decarboxylase Diphosphomevalonate decarboxylase (), most commonly referred to in scientific literature as mevalonate diphosphate decarboxylase, is an enzyme that catalyzes the chemical reaction :ATP + (R)-5-diphosphomevalonate $\backslash rightleftharpoons$ ADP + phosphate + isopentenyl diphosphate + CO2 This enzyme converts mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP) through ATP dependent decarboxylation.〔 The two substrates of this enzyme are ATP and mevalonate 5-diphosphate, whereas its 4 products are ADP, phosphate, isopentenyl diphosphate, and CO2. Mevalonate diphosphate decarboxylase catalyzes the final step in the mevalonate pathway. The mevalonate pathway is responsible for the biosynthesis of isoprenoids from acetate. This pathway plays a key role in multiple cellular processes by synthesizing sterol isoprenoids, such as cholesterol, and non-sterol isoprenoids, such as dolichol, heme A, tRNA isopentenyltransferase, and ubiquinone. This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP isopentenyl-diphosphate-forming). Other names in common use include pyrophosphomevalonate decarboxylase, mevalonate-5-pyrophosphate decarboxylase, pyrophosphomevalonic acid decarboxylase, 5-pyrophosphomevalonate decarboxylase, mevalonate 5-diphosphate decarboxylase, and ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating). ==Enzyme mechanism== Mevalonate diphosphate decarboxylase recognizes and binds two substrates: ATP and mevalonate 5-diphosphate. After binding, the enzyme performs three types of reactions that can be separated into two main stages. First, phosphorylation occurs. This creates a reactive intermediate, which in the second stage undergoes concerted dephosphorylation and decarboxylation. Many enzyme residues in the active site play important roles in this concerted mechanism. A serine residue deprotonates the hydroxyl on MVAPP and facilitates the oxygen to attack a phosphate from ATP. As a result, intermediate 1, 3-phosphoMVAPP, now has a much better leaving group, which helps to produce intermediate 2.〔 This third intermediate is a transient beta carboxy carbenium intermediate and provides an "electron sink" that helps drives the decarboxylation reaction.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Diphosphomevalonate decarboxylase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.